Knowledge of where all the functional elements are located in a eukaryotic genome cannot by itself unleash an understanding of gene regulation as these elements operate in the context of chromatin, where DNA is wrapped around a core of eight histone proteins and packaged into higher order structures. Our research aims to provide a better understanding of where the functional elements reside in relation to nucleosomes.
|Maps of the Saccharomyces genome|
|Nucleosome maps of the Drosophila genome|
|Genomic organization of human transcription initiation complexes|
|Data storage and computational resources|
|Bioinformatics: Genetrack, Genie, LionDB|
We seek to foster collaborative, interdisciplinary research into fundamental gene regulation processes and their impact on cellular and developmental biology.