The Penn State Genome Cartography Project is a collaboration
between Penn State's
Center for Eukaryotic Gene Regulation
and
Center for Comparative Genomics and Bioinformatics
to map DNA sequence features, protein-nucleic acid interactions, and other
information to the genomes of model organisms, and present that
information in a visually cognitive way that provides a discovery
pathway for biological knowledge.
Knowledge of where all the functional elements are located in a eukaryotic genome cannot by itself unleash an understanding of gene regulation as these elements operate in the context of chromatin, where DNA is wrapped around a core of eight histone proteins and packaged into higher order structures. Our research aims to provide a better understanding of where the functional elements reside in relation to nucleosomes.
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Maps of the Saccharomyces genome |
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Nucleosome maps of the Drosophila genome |
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Data storage and computational resources |
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Bioinformatics: Genetrack, Genie, LionDB |
We seek to foster collaborative, interdisciplinary research into fundamental gene regulation processes and their impact on cellular and developmental biology.
